Research Progress of DYRK1A in Nervous System Development and Disease
YU Yuanyi, LUO Fucheng*
DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A) is a highly evolutionary conserved protein kinase. It plays an important role in regulating biological processes such as biothythm, glycogen synthesis and cell cycle progression. In recent years, more and more studies have shown that DYRK1A can also regulate the functions of neurons and glial cells, and participate in the pathologic processes of neurological diseases such as Down syndrome, autism, Alzheimer’s disease and Parkinson’s disease. This review systematically summarized the function of DYRK1A in different types of nerve cells and its role in the pathogenesis of nervous system in recent years, aiming to provide valuable information for the study of DYRK1A.
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