Home > Browse Issues > Vol.28 No.5
Nuclear Transport Receptor， Importinβ Family Proteins， and the Regulation Mechanisms in Nucleocytoplasmic Transport
Xiao Wang, Yu-Peng Wang, Yu Quan, Zhi-Liang Ji, Tao Tao*
Key Laboratory of Ministry of Education for Cell biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
Abstract: Nucleocytoplasmic transport of macromolecules is mediated by the soluble transport receptors collectively named Importinβ super family proteins. RanGTP regulates the interactions between the receptors and cargos. In this review， we describe the structural features of Importinβ family proteins and possible regulation mechanisms in nucleocytoplasmic transport of large molecules， such as modulating the NLS/NES directly by phosphorylation， or covering the NLS/NES domain through polymerization. The precise regulation of nucleocytoplasmic transport brings cargos to the correct subcellular locations， which is essential for the cargos' cellular functions such as gene transcription regulation， cell cycle regulation， cell differentiation and proliferation. Disruption of the nuclear import/export processes will result in the mislocation of cargoes， therefore causing developmental disorder and diseases.
CN
EN