Research Progress on the Role of TGF-β Signaling Pathway in Neurodegenerative Diseases

LU Yi¹, ZHANG Lihan¹, PAN Xuyi², FANG Yuanyuan^1,3, YAN Yue², WANG Wei³*, MIAO Xuemeng^1,3*, HUANG Zhihui^1,3,4*

(¹The First Clinical Medical College, Wenzhou Medical University, Wenzhou 325035, China; ²The Second Clinical Medical College, Wenzhou Medical University, Wenzhou 325035, China; ³School of Mental Health, Wenzhou Medical University, Wenzhou 325035, China; ⁴School of Medicine, Hangzhou Normal University, Hangzhou 311121, China)

Abstract:

Neurodegenerative diseases are a type of diseases with poor prognosis and incurable in which the body’s neurons or myelinations are progressively lost due to various reasons, and eventually dysfunction occurs. TGF-β (transforming growth factor-β) signaling pathway can regulate a variety of cellular processes, including cell growth, cell differentiation, cell apoptosis, etc., and plays an important role in maintaining normal development and homeostasis of the body. Previous studies have shown that the TGF-β signaling pathway is closely related to the occurrence, development and treatment of neurodegenerative diseases. This paper introduces the latest research progress of TGF-β signaling pathway in various neurodegenerative diseases, in order to provide new ideas for the prevention, diagnosis and treatment of neurodegenerative diseases.

CSTR: 32200.14.cjcb.2022.10.0013