TAB2/TAB3: Important Components Involved in the Activation and Regulation of Inflammation

TAB2 (TAK1 binding protein 2) and TAB3 (TAK1 binding protein 3), two homologous proteins of TABs [TAK1 (transforming growth factor-β-activated kinase 1) binding proteins], as key components of the TAK1-TABs complex, mediate the activation of the MAPK (mitogen-activated protein kinase) and NF-κB (nuclear factor kappa-B) signaling cascades to promote the occurrence of inflammation. Moreover, the expression levels of TAB2/TAB3 and their post-translational modifications play an important role in the regulation of inflammation. This paper focuses on a brief review of the role of TAB2/TAB3 in the processes mentioned above.

CSTR: 32200.14.cjcb.2022.10.0010