Research Progress on Neural Crest Cells
GONG Xiaoxue, LOU Jianlin*
Neural crest cells are a temporary cell population produced by embryonic ectoderm cells during development. Neural crest cells have the characteristics of self-renewal and pluripotent differentiation. Neural crest cells have strong migration ability and can reach any position of the embryo. They can colonize and become progenitor cells or differentiate into different cell lines, including neurons of the peripheral nervous system, endocrine cells, smooth muscle cells and tendon cells. This cell population is widely involved in the process of tissue damage repair and is associated with substantial organ fibrosis. This article reviews the biological characteristics, migration and differentiation mechanism of neural crest cells, as well as their role in tissue injury repair and their role in fibrosis.
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