Research Advances of Tumor-Associated Macrophage and It’s Targeted Therapy
JIANG Qi1, ZHENG Xin1,2, SHEN Huan2, DONG Cheng2, WANG Hongyan1,2*
Tumor is closely related to the immune system, and this disease has high death rates next to cardiovascular diseases. TAM (tumor associated macrophage) plays an important role as the main immune cell subset in TME (tumor microenvironment). More infiltrating M2-TAM is related to the lower survival rate of solid tumor patients. Understanding of metabolic changes and functional plasticity of TAM in the TME can help to develop effective tumor immunotherapy. This review summarizes the latest researches about the origin, functional plasticity, metabolic changes of TAM. It also focuses on the targeted therapies of TAM in solid tumors, aiming to provide new ideas for tumor immunotherapy.
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