The Effects and Mechanisms of FOXA1 on Hormone-Dependent Tumors

The normal operation of the mechanism in animals depends on the interaction between transcription factors in vivo, but the abnormal expression of transcription factors can cause cell mutation or carcinogenesis. The pioneer transcription factor FOXA1, also known as hepatocyte nuclear factor 3α, has important regulatory roles in endoderm-derived pancreatic and renal organ development. Recently, it has been found that the interaction between the FOXA1 and the hormone receptors play roles in the occurrence and progression of hormone-dependent tumors, especially in prostate cancer. In recent year, three types of mutations in FOXA1 and their key regulatory roles in tumorigenesis and development have been discovered. This paper mainly summarized the role and mechanism of FOXA1 in hormone-dependent tumors, including breast cancer, prostate cancer, ovarian cancer and endometrial cancer. As targeting FXOA1/FOXA1-related hormone receptors is difficult, this article further summarizes the post-translational modifications of FOXA1 and potential therapeutic targets related to FOXA1. A brief summary of the expression of FOXA1 in other cancer types and its correlation with prognosis is also provided.

CSTR: 32200.14.cjcb.2022.09.0017