Research of Legumain in Tumor Microenvironment
KANG Jin1, XUE Kaikai2, FAN Yarong2, ZHANG Xiaolong2, ZHANG Qing2, DONG Li2, LIU Xiaochun1 *
Tumor microenvironment is an important determinant in the process of tumorigenesis and development, and is affected by abnormal expression or structural changes of various proteins in cells. Legumain, a cysteine protease, is involved in the processing of various proteins and exerts certain biological functions in vivo. At the same time, it is highly expressed in various tumors and is closely related to the invasion, spread and metastasis of malignant tumors. Its specific biological mechanism involves multiple pathways and may affect the tumor microenvironment, including tumor-associated macrophages and vascular endothelial cells. This article will review the mechanism of Legumain in tumor formation and progression and its relationship with tumor microenvironment, so as to provide a scientific basis for systematically elucidating the mechanism of Legumain in tumor microenvironment and exploring new biomarkers for tumor diagnosis and treatment.
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