This work was supported by the National Natural Science Foundation of China (Grant No.31960162)

It is a promising therapeutic strategy to treat tumors by using the host organism’s own immune response and inflammatory response. More and more evidence shows that TLRs (Toll-like receptors) are the key receptors in innate immunity and play an important role in the occurrence and development of cancer. Different Toll-like receptors may have different anti-tumor effects, and they can stimulate the occurrence of anti-tumor immunity by initiating innate immune response and adaptive T cell immunity. It can also affect the development of tumor by activating inflammatory reaction, so TLR as a potential therapeutic target has attracted more and more attention, and its agonist has been actively studied for its anti-tumor potential. In this context, the flagellin of Salmonella typhimurium has been identified as a potential tumor therapeutic agent capable of inducing tumor regression, and this therapeutic effect is thought to be mediated by the TLR family pattern recognition receptor TLR5-mediated bacterial antigenicity and mediated by the activation of the host innate immune response, but its exact mechanism of action is not fully understood. The current research results show that TLR5 can specifically recognize flagellin, It is a promising therapeutic strategy to treat tumors by using the host organism’s own immune response and inflammatory response. More and more evidence shows that TLRs (Toll-like receptors) are the key receptors in innate immunity and play an important role in the occurrence and development of cancer. Different Tolllike receptors may have different anti-tumor effects, and they can stimulate the occurrence of anti-tumor immunity by initiating innate immune response and adaptive T cell immunity. It can also affect the development of tumor by activating inflammatory reaction, so TLR as a potential therapeutic target has attracted more and more attention, and its agonist has been actively studied for its anti-tumor potential. In this context, the flagellin of Salmonella typhimurium has been identified as a potential tumor therapeutic agent capable of inducing tumor regression, and this therapeutic effect is thought to be mediated by the TLR family pattern recognition receptor TLR5-mediated bacterial antigenicity and mediated by the activation of the host innate immune response, but its exact mechanism of action is not fully understood. The current research results show that TLR5 can specifically recognize flagellin,

CSTR: 32200.14.cjcb.2022.09.0014