Research Progress of miRNA in Intracranial Aneurysm

IA (intracranial aneurysm) is a vascular wall dilation caused by intracranial artery vascular injury and other factors. The onset is insidious, and most of them have no obvious clinical symptoms. If they are not diagnosed in time, they will lead to subarachnoid hemorrhage, which seriously endangers human physical and mental health. The pathogenesis of IA is not fully understood and needs to be further explored. In recent years, it has been found that miRNAs are involved in the pathogenesis of IA and play an important role in their formation, growth and rupture. It has great potential application value in the early prediction, diagnosis and prognosis of aneurysm rupture. Therefore, it can be used as an ideal molecular biomarker to identify intracranial aneurysm or predict its rupture. This paper reviews the role of miRNAs in vascular pathophysiology, and explores the potential value of miRNAs in the formation, rupture and subarachnoid hemorrhage caused by intracranial aneurysms, in order to provide a new basis for the early diagnosis, clinical treatment and prognosis of intracranial aneurysms.

CSTR: 32200.14.cjcb.2022.09.0012