Application of Growth Factors in Tendon Tissue Regeneration
DING Nanhao, FAN Chunmei, CHEN Xiao*
Tendon injury is a common global health problem. The properties of tendons make their natural healing difficult and scar tissues often replace the natural tissues in the injured site after healing, which results in biomechanical damage of tendon. In recent years, many evidences suggest that growth factors play an important role in the regeneration and healing of tendons, which develops a new direction for the treatment of tendon injury. In this review, the major growth factors have been applied to treat tendon injuries so far are summarized with their effects and delivery strategies. It is indicated that the combination of growth factors, stem cells and biological scaffolds may be used in tendon tissue engineering to achieve the elimination of tendon scar and the individualized regeneration of tendons as well.
CN
EN