Asymmetric Division of Muscle Stem Cell in Muscular Disease

LI Hu^1#, HAN Wanhong^2#, ZHU Dahai¹, ZHANG Yong²*

（¹Bioland Laboratory, Guangzhou 510535, China; ²Chinese Academy of Medical Sciences and School of Basic Medicine, Beijing 100005, China)

Abstract:

Skeletal muscle is the largest metabolic and secretory organ of the human body, and has a strong regenerative ability. MuSCs (muscle stem cells) play an indispensable role in skeletal muscle development, regeneration and homeostasis. During muscle regeneration, MuSC is activated and re-enters the cell cycle to proliferate, differentiate, and repair the damaged fibers. MuSCs undergo a symmetric cell division to generate a stem cell and a myogenic progenitor. Abnormal asymmetric division of MuSCs is one of the causes of muscle diseases (aging, duchenne muscular dystrophy). This review will discuss the mechanisms of MuSC polarity and asymmetric division and their effects in muscle diseases. Finally, the therapeutic feasibility of targeting asymmetric division of MuSC to treat muscle diseases will be summarized.

CSTR: 32200.14.cjcb.2022.08.0011