Research Progress of Neural Circuit Regeneration
PENG Cheng1,2,3, LIU Yanmei1*, FEI Jifeng2,3*
Injuries of nervous system often result in damage or defect to the neural circuits, and induce dysfunction or loss of function that is originally modulated by those circuits, exerting massive obstacle to patient’s daily life. Therefore, treatment to nervous system injury mainly aims to reestablishing the connectivity of neural circuits and recovering the function. In recent years, there have been a series of research progresses in investigating neural circuit reestablishment by new born neurons replacing lost cells and integrating into lesioned circuits. Mammals could achieve certain circuit repair and functional recovery by endogenous neurogenesis or implanting exogenous neural stem cells, meanwhile lower vertebrates are able to relatively perfectly regenerate lesioned neural tissue by intrinsic neurogenesis. Investigating these model animals also reveals many factors that could promote regeneration and the mechanisms that rebuild the connectivity of lesioned neural circuit. This review briefly summarized recent advances of these research aspects
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