Advances in the Study of Yap in the Regeneration of Mammalian Visceral Organs
YIN Binxu, WANG Heng*
Injuries and diseases of internal organs such as the heart, lung and liver cause significant damage to human health. Unfortunately, a certain variation of the repair and regeneration abilities of different organs exists in mammals, including humans. Among different organs, the heart has basically no regenerative ability, the lung can regrow compensatively after injury, and the liver can be restored to a normal liver-to-body weight ratio after injury. Studying the molecular mechanisms of repair and regeneration of internal organs such as heart, lung and liver in model animals have important implications for clinical treatment of related diseases. It was found that Yap, a core transcriptional regulatory molecule of the Hippo pathway, has important regulatory roles in cell proliferation and differentiation. Hippo/Yap, can sense and respond to various microenvironmental changes after injury, initiating and participating in the regeneration process of several organs. This review focuses on the role of Yap in the regeneration process of heart, lung and liver and the underlying regulatory mechanisms.
CN
EN