Recent Advances on Cardiomyocyte Dedifferentiation and Proliferation during Heart Regeneration
XIAO Chenglu*
Myocardial infarction is a serious threat to human life and health. The damaged adult mammalian heart is unable to regenerate, eventually leading to heart failure. A variety of clinical treatments can relieve the symptoms of myocardial infarction, but they cannot repair the dead heart cells. Lower vertebrates such as zebrafish and some newborn mammals can regenerate damaged hearts. Research on cellular and molecular mechanisms of cardiac regeneration can provide theoretical basis for the repair of adult cardiac injury. More and more studies have shown that cardiomyocyte repair after cardiac injury depends on the dedifferentiation and proliferation of cardiomyocytes. In this paper, the origin of cardiomyocytes during cardiac regeneration and the molecular mechanisms of the dedifferentiation and proliferation of cardiomyocytes are briefly reviewed.
CN
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