Membrane Damage and Repair—Lessons from C. elegans

WANG Yuanyuan¹, MENG Xinan^2,3, XU Suhong^1,2,3*

（¹Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; ²Zhejiang University-University of Edinburgh Institute, Haining 314400, China; ³Department of Burn and Wound Repair of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China)

Abstract:

The cell membrane is an important barrier for maintaining the homeostasis of the intracellular environment. The integrity of cell membrane can be affected by pathogens, chemicals, radiation, inflammatory responses, and mechanical stress. The self-healing of the cell membrane after injury determines whether cells can restore their functions for survival, and also determines whether the corresponding organism can maintain its normal structure and activity. Previous studies in the field have found that different membrane repair mechanisms are involved in restoring the structural and functional integrity of the cell membrane, depending on the type and size of “injury”. This review will firstly summarize the previous research findings on the mechanisms of cell membrane repair, and then focus on the recent in vivo studies in membrane repair by using the adult C. elegans epidermal cell.

CSTR: 32200.14.cjcb.2022.08.0002