The Research Progress on Ameliorating Diabetic Cardiomyopathy via Exercises
FU Yu1, ZHONG Yuanming2, LÜ Yi1*
DC (diabetic cardiomyopathy) is a myocardial disease caused by diabetic homeostasis disorder, which is one of the main causes of death in diabetic patients. Its pathological features are heart structural damage and dysfunction, which lead to heart failure. The pathogenesis of DC is complex, including a variety of mechanisms, such as metabolic disorders, mitochondrial dysfunction, Ca2+ homeostasis imbalance, and excessive apoptosis and fibrosis of cardiac myocytes. In recent years, several studies have proved that physical training has significant effects on the prevention and treatment of diabetes. In addition to the beneficial effects on systemic changes associated with diabetes recovery, exercise ameliorates multiple metabolic dysfunctions in DC. On the one hand, high systolic activity of the organism during exercise can directly recover cardiac injury caused by DC through accelerating cardiac metabolism and cardiogenic structural damage repairment. On the other hand, exercise can indirectly alleviate the pathological development of DC by reducing circulating blood sugar and fat as well as increasing insulin sensitivity. However, the molecular mechanism of how exercise mediates DC recovery remains unknown. To provide a clue for the development of new therapeutic strategies, this study reviewed the current molecular mechanisms on alleviating DC by exercises.
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