Research Progress of Exosomes Derived from Mesenchymal Stem Cells in the Treatment of Ischemic Stroke

CHEN Deyi¹, SU Gang², CHEN Lixia¹, LIU Jifei¹, LIU Zhe³, ZHANG Zhenchang¹*

(¹Department of Neurology, Lanzhou University Second Hospital, Lanzhou 730030, China; ²Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China; ³School of Basic Medical Sciences, Gansu University of Chinese Medicine, Lanzhou 730000, China)

Abstract:

Exosomes are extracellular vesicles with a diameter of 30~150 nm, containing bioactive molecules such as nucleic acids and proteins derived from cells, which play pivotal roles in intercellular communication processes. Exosomes derived from mesenchymal stem cells can effectively transport bioactive substances, such as mRNA, microRNA, protein and so on. Exosomes have many important biological functions such as promoting angiogenesis, reducing inflammatory response, regulating autophagy levels, inhibiting apoptosis and pyrolysis. It has a good prospect of clinical application in improving the prognosis of neurological diseases. In this paper, the neuroprotective effects and mechanisms of exosomes derived from mesenchymal stem cells on ischemic stroke were summarized, and the applications of targeted and modified exosomes in the treatment of ischemic stroke were discussed, in order to provide a reference for subsequent studies.

CSTR: 32200.14.cjcb.2022.07.0021