Home > Browse Issues > Vol.44 No.7
The Roles of Kallikrein-Related Peptidases in Tumors
TU Xiancong#, LIU Xiaowen#, FAN Yanmei, ZHAO Hongcheng, WANG Yueqing*
(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Medical College, China Three Gorges University, Yichang 443002, China)
Abstract:
The family of KLKs (kallikrein-related peptidases) is the largest known serine protease family in human. KLKs mainly exist in body fluids and tissues, and participate in a wide range of physiological processes. Their abnormal regulation is closely related to tumor formation and development. This article summarizes the relevant mechanisms of KLKs involved in tumorigenesis and development, as well as the important role of some KLK members in tumor, and reviews the research progress of their mediation in cancer progress, and as the tumor biomarkers or candidate targets for therapy.
CN
EN