Home > Browse Issues > Vol.28 No.4
The Fuction of Survivin in Cell Division
Jian-Ying Wang, Zou-Ran Lan1, Xing-Hua Yu2, Yun-Long Li*
Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan 250014, China;1Life Sciences and Technology College, Ocean University of China, Qingdao 266003, China;2College of Life Science,
Abstract: Survivin is a new inhibitor of apoptosis (IAP) protein. Survivin， is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner and it has two different subcellular localization. Survivin initiates cell cycle entry and is required for centrosome assembly， spindle assembly checkpoint surveillance and cytokinesis. Survivin also plays a role in meiosis， but there are only a few reports to date. The survivin activity resulted from the phosphorylation of Thr34 by the mitotic kinase complex p34cdc2-cyclin B1， many factors regulate its expression level.
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