Research Progress and Significance of Selective Autophagy Receptor TAX1BP1

Autophagy is one of the main degradation systems in eukaryotic cells and plays an important role in removing damaged substances in cells. In recent years, the relationship between autophagy and disease has become a hot topic. Abnormal autophagy often affects the occurrence, development and prognosis of diseases. The process of selectively clearing some cytoplasmic components through autophagy is called selective autophagy. The occurrence of selective autophagy usually requires the participation of autophagy receptors, and different autophagy receptors play different functions. Among them, TAX1BP1 (Tax1-binding protein 1), as a member of selective autophagy adaptor protein, is mainly composed of a SKICH (SKIP carboxyl homology domain), a microtubule associated protein I light chain 3 binding region, three coiled coils and a C-terminal ubiquitin binding domain. These domains mediate the interaction between TAX1BP1 and other proteins, and affect the function of TAX1BP1 in cells to a certain extent. TAX1BP1 simultaneously regulates NF-κB, JNK and other signal pathways. It is widely involved in autophagy processes such as mitophagy, xenophagy and lysophagy. The abnormal expression of TAX1BP1 is closely related to inflammation, malignant tumors and circulatory diseases. This paper will systematically summarize the structure and function, regulated signal pathway, relationship with autophagy and the physiological significance of TAX1BP1, so as to provide new ideas for the research of TAX1BP1 in the future.

CSTR: 32200.14.cjcb.2022.03.0012