The Role of Autophagy on Muscle Stem Cells during Regeneration
CHEN Wei1,2,3,4, CHEN Yushi1,2,3,4, LIU Yuxi1,2,3,4, WANG Xinxia1,2,3,4*
Various hereditary defects, substantial tissue damage, or alterations in extrinsic signalling could impair the regeneration of muscle tissue and lead to various primary or secondary myopathies. Therefore, understanding the physiological processes and related molecular mechanisms in muscle regeneration will contribute to more effective combined treatment strategies. Autophagy was initially considered as the mechanism of nutrient decomposition. Subsequent studies further find that autophagy is also a physiological process of degrading cytoplasmic components, protein aggregates and organelles, which is a regulator of cell structure and widely participates in the process of cell stress and differentiation. The studies of autophagy inhibition show that autophagy is essential for successful muscle regeneration, and one of the key mechanisms is to affect the differentiation fate of MuSCs (muscle stem cells). Therefore, understanding the role of autophagy will contribute to more effective clinical treatment. Here, this article reviews the literature on the role of MuSCs in muscle regeneration by autophagy in recent years, so as to provide relevant references for the treatment of regeneration deficient myopathy by regulating autophagy.
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