Research Progress of Thyroid-Related Hormones and Gestational Diabetes Mellitus

ZHAO Zhijia¹, CHEN Yanming¹, WU Yifan², YE Ke², JIANG Jing², JI Lindan^3,4*, XU Jin^1,4*

(¹Department of Preventive Medicine, Ningbo University School of Medicine, Ningbo 315211, China; ²Department of Clinical Medicine, Ningbo University School of Medicine, Ningbo 315211, China; ³Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Ningbo 315211, China; ⁴Zhejiang Key Laboratory of Pathophysiology Technology Research, Ningbo 315211, China)

Abstract:

Thyroid-related hormones participate in the regulation of glucose homeostasis, and their levels could be significantly influenced by many maternal hormones during pregnancy. Studies have found that thyroidrelated hormone levels and thyroid dysfunction are closely related to the occurrence of GDM (gestational diabetes mellitus). In addition, genetic variants in thyroid function-related genes may also affect the risk of GDM. However, the specific pathological mechanism of the aforementioned three aspects in GDM is still unclear. This review systematically described the roles of thyroid-related hormones, thyroid dysfunction and genetic variation of thyroid function-related genes in the pathological mechanism of GDM, which may provide information for future prevention and treatment of thyroid function-related GDM.

CSTR: 32200.14.cjcb.2022.03.0010