Research Progress of Targeting Ras Signal Pathway Inhibitors in Tumor Therapy
LI Qingyun#, LIU Xiaowen#, DENG Hao, XIANG Fengyi, WANG Yueqing*, TAN Xiao*
The Ras signaling pathway plays an important role in the development of tumors. This pathway is closely related to tumor proliferation, metastasis and apoptosis. However, no targeted drugs have been identified for clinical use. In recent years, inhibitors targeting Ras signaling pathway have been widely studied and achieved good efficacy in clinical trials. This article focuses on the relationship between the Ras signaling pathway and tumors, and the research and development progress of inhibitors targeting the upstream and downstream of Ras signaling. In addition, the research progress of covalent inhibitors against Ras protein and combination drug strategies are also summarized. This paper points out the challenges of targeting Ras signaling pathway, and the future direction is to improve the structure of inhibitors, clarify the specific mechanism and combine treatment strategies.
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