Research Progress of Signaling Pathways and their Interactions in Inner Ear Hair Cell Regeneration
YANG Ying1, CHEN Fengjiao1, LU Tingting2, LU Yin3, DING Jie1*
Hair cells are sensory receptors located in the inner ear, which are responsible for converting mechanical sound energy into nerve impulses, allowing the body to perceive external sounds. In mature mammals, when hair cells in the inner ear are destroyed, they cannot regenerate and cause permanent sensor neural hearing loss. Researchers simulated the injury of the inner ear in mammals and found that the Notch signaling pathway forms new sensory hair cells through lateral inhibition and lateral induction. Notch’s downstream signal Wnt and upstream signal FGF-FGFR are the key signal pathways that promote inner ear development, cell proliferation, differentiation and hair cell regeneration. Therefore, it is extremely important to understand the mechanism of Notch, Wnt, FGF and other signaling pathways and related transcription factors in the process of mammalian inner ear haircell regeneration. This article focuses on the regulation of the Notch signaling pathway and the interaction of related signal molecules in the regeneration of inner ear hair cells, aiming to analyze the regulation mechanism of cochlear hair cell proliferation and regeneration, and provide theoretical reference for experimental research and clinical application of deafness treatment.
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