Biological Characteristics of Tyrosine Kinase Fyn and Its Function in Tumorigenesis and Tumor Progression

LI Ang¹, PU Xinyuan¹, JIANG Yu¹, ZHANG Haihui¹, HUANG Jian¹, XU Weirong²*

(¹Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; ²Center for Laboratory Instruction in Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China)

Abstract:

Fyn kinase, a member of SFKs (Src family kinases), may be closely related to metabolism, proliferation and migration of tumor cells, functioning as an important regulator in tumorigenesis. In this review, the fundamental properties, the related signal pathway and the basic physiological functions of Fyn are discussed to illuminate the molecular characteristics of Fyn. Furthermore, current research progress of Fyn and its promoting effects in the oncogenesis of glioma, hematologic neoplasms, and pancreatic neoplasms are specially summarized. Based on that, this review proposes the directions for the subsequent study of tumor targeted therapy.

CSTR: 32200.14.cjcb.2022.03.0007