Orexinergic System and Substances Addiction

Addiction, a serious form of substance use disorder, is a chronic brain disease characterized by the dysfunction of reward, motivation, memory and other functions and induces serious individual and social problems. Orexins are neuropeptides secreted by hypothalamic orexinergic neurons, which are not only involved in regulation of physiological functions of the nervous system, but also closely related to many nervous diseases. Furthermore, the roles of orexins in substances addiction are getting more and more attention, and it has been proved that orexins play important roles in a variety of substances addiction. However, the underlying mechanisms have not been fully elucidated and are needed to be further explored. Therefore, this paper reviews the research progress on orexinergic system in substances addiction, in order to provide new ideas for the researches and treatments of substances addiction.

CSTR: 32200.14.cjcb.2022.02.0017