The Progress of Cryoablation in Tumor Immunotherapy
DENG Xiangling1, WANG Xin2, SHEN Yangkun1*
Cryoablation is a minimally invasive surgery for tumors. It has the advantages of small trauma and precise treatment for local tumor treatment. It has been widely used in the treatment of solid tumors such as liver, kidney, prostate, lung and breast cancer. Different from traditional radiation therapy, microwave radiofrequency and other physical therapies, cryoablation induces tumor antigens released by tumors to be closer to the natural state, which can effectively activate T cells to recognize tumor antigens for the production of anti-tumor immunity. The combination therapy provides the basis. Therefore, it is a new direction in the field of tumor immunotherapy to find suitable cryoablation combined therapy drugs to comprehensively enhance the body’s immune response. This review discusses the molecular mechanism of cryoablation in the treatment of tumors and the effective anti-tumor immune response it induces. In addition, it reviews the therapeutic effects of cryoablation combining with different immunotherapies in recent years, hoping to provide new treatment strategies for tumor treatment.
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