Research Progress of MMP-13 in Skin-Related Diseases

LIU Wenqi¹, CHEN Jialong², HAN Yang¹, ZHANG Xinrui¹, CHEN Juan¹, QI Ruiqun², LI Xiaodong¹*

( ¹Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, China; ²Department of Dermatology, the First Hospital of China Medical University, Shenyang 110001, China)

Abstract:

MMPs (matrix metalloproteinases) are zinc dependent proteolytic metalloenzymes. MMP-13 belongs to the collagenase subgroup and plays important roles in extracellular matrix circulation, cancer cell migration, cell growth, inflammation, angiogenesis, etc. It can degrade collagen, gelatin and aggregated proteoglycan. The expression of MMP-13 in photoaging can be affected by multiple signaling pathways such as MAPK, NF-κB and TGF-β. In cancer cells, MMP-13 can be degraded through extracellular matrix, leading to invasion and metastasis of tumor cells. It may directly regulate several signaling pathways that control tissue homeostasis. In this paper, the research of MMP-13 in skin-related diseases is reviewed.

CSTR: 32200.14.cjcb.2022.02.0012