Molecular Mechanism Regulating the Development of Hematopoietic Stem Cell to the Erythroid System

ZHANG Xuan¹, WANG Wanying², LÜ Tao^1,3*

(¹Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China; ²Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650504, China; ³Department of Medical Genetics, the First People’s Hospital of Yunnan Province, Kunming 650032, China)

Abstract:

The differentiation of HSC (hematopoietic stem cell) into RBC (red blood cell) is a precise and complex process, which is tightly regulated from lineage determination to terminal differentiation, enucleation and organelle clearance. The disorders of red blood cell production can lead to various diseases. The key to treating these diseases is to clarify the exact regulation mechanism of erythroid development. This review mainly summarizes the recent research on the regulatory factors at the molecular level, including the regulation of transcription, post-transcription, translation and post-translation. It will help to improve the regulatory network of erythroid differentiation, understand the pathogenesis of erythrocyte dysplasia and find new treatment strategy.

CSTR: 32200.14.cjcb.2021.12.0021