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Roles of Jagged1 in the Immuno-tolerance Induced by Dendritic Cells
Zhen-Ping Teng, Fei-Yue Xing*, Zhe Yu, Yao-Ying Zeng
Institute for Tissue Transplantation and Immunology, Key Laboratory of Minister of Education,Jinan University, Guangzhou 510632, China
Abstract: Jagged1 is one of ligands from Notch receptors in vertebrates. Recently, many researches indicate that it may induce maturation of dendritic cells, and that it may promote T lymphocytes to deviate to regulatory T cells or T-helper 2 cells, which results in the immuno-tolerance.