Research Progress on Expression and Activity Regulation of SREBP2
WANG Lulin, ZHANG Shuojie, MA Ping, DAN Juhua*
Cholesterol homeostasis is very important to cells and organisms. REBP2 (sterol-regulatory element binding protein 2) is a key regulator of cholesterol homeostasis located in the endoplasmic reticulum to sense cholesterol changes. The expression and functions of SREBP2 are mainly regulated at three levels: (1) transcriptional regulation of SREBF2 gene, (2) transport and splicing regulation of SREBP2 protein, and (3) modification and functional regulation of nSREBP2. This study summerizes the research progress of the above three stages of regulation and their role in metabolic diseases, which will provide a theoretical reference for targeting SREBP2 to study cholesterol metabolism and the treatment of diseases related to abnormal metabolism.
CN
EN