Research Progress on Parkin in Regulating Apoptosis, Necroptosis and Pyroptosis

LI Quan¹, QUAN Meiyu², ZHANG Jinsan^2,3*

( ¹College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China;²Key Laboratory of Interventional Pulmonology of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; ³Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou 325035, China)

Abstract:

There exist multiple cell death pathways, including apoptosis, necroptosis and pyroptosis, which are defined by different signaling and execution pathways, and play disparate roles in a wide range of cellular processes. The functions and mechanisms of cell death have been intensively studied in recent years, and a great progress has been made toward understanding the molecular machinery of cell death pathways. Parkin, an E3 ubiquitin ligase, exhibits a plethora of biological activities in various cellular processes by ubiquitination of its specific substrates. In addition to its well-characterized activities in mediating mitophagy, recent studies also highlight its roles in regulating cell death pathways and pathogenesis of cancer via direct ubiquitination of several characteristic “death” substrates. This review summarizes the recent advance in the role and the action mechanism of Parkin in cell death pathways with a focus on apoptosis, necroptosis and pyroptosis, which provides in-depth comprehension of mitophagy-dependent, as well as independent, revealing the biological mystery associated with cell death.

CSTR: 32200.14.cjcb.2021.12.0018