Research Progress of Linear Ubiquitination
CHEW Sienping, TAN Xinyi, TAN Hongxiang, XU Weirong*
Linear ubiquitination is a new kind of ubiquitin modification. Compared with the polyubiquitination mediated by lysine, linear ubiquitination mainly involves head-to-tail connection between ubiquitin molecules. Linear ubiquitination is mediated by LUBAC (linear ubiquitination complex), an E3 ligase, which participates in myriad cellular activities including anti-apoptosis, antiviral effect, and inflammation of cells. This review mainly introduces the composition and the modification ways of linear ubiquitination, the signaling pathways that linear ubiquitination has participated in, and its epigenetic regulatory roles in pathogenesis of diseases such as tumors, autoimmune diseases, etc.
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