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Research Advances on Extrachromosomal Circular DNA
WANG Fengjuan, QU Shuang, LIANG Hongwei*
(School of Life Sciences and Technology, China Pharmaceutical University, Nanjing 211198, China)
Abstract:
eccDNA (extrachromosomal circular DNA) is a kind of circular DNA molecule in eukaryotes. It is a kind of special genetic material and carry complete genes which can express functional protein or RNA. eccDNA can be generated by DNA from endogenous genome and exogenous DNA in cells. Several studies have proved eccDNA can participate in various physiological and pathological processes, such as aging and tumorigenesis. In this paper, the authors review the research progress of eccDNA and elaborate the relationship between eccDNA and tumor.
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