Biological Characteristics of Residual Hematopoietic Cells in Aplastic Anemia
YANG Wenrui, ZHANG Fengkui*
AA (aplastic anemia) is a rare bone marrow failure disorder mainly due to T cell immunemediated destruction of hematopoietic precursor cells. The hematopoiesis of AA was characterized by both a severe decrease quantitative and qualitative defect of the HSCs (hematopoietic stem cells), with similar properties to aging HSCs. With the damage of immune attack and hematopoietic pressure, the remaining progenitor and stem cells showed lower clonogenic capacity, poorly responsive to cytokines, shortened telomeres and genetic instability; or some of them escaped from immune attack, while the propensity to undergo clonal hematopoiesis and transformation to MDS/AML was significantly increased
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