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Heterogeneity and Clonal Evolution of Myeloproliferative Neoplasms
SONG Junzhe, YUAN Jiajia, ZHOU Yuan*
(State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China)
Abstract:
MPNs (myeloproliferative neoplasms) are a group of chronic hematological neoplasms characterized by the proliferation of mature myeloid cells. Patients with MPNs show a significantly greater degree of heterogeneity in genetics, clinical phenotype, and cancer metabolism. The clonal evolutionary process is regulated by various intrinsic and extrinsic factors including mutations in HSCs (hematopoietic stem cells), inflammatory bone marrow microenvironment and immune dysfunction. Here, recent advances in the pathogenesis of MPN from the perspective of heterogeneity and clonal evolution are summarized.
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