Lipid Metabolism in Hematopoietic Stem Cell Development and Function
SUN Lina, WANG Lu*
HSCs (hematopoietic stem cells) are a population of multipotent stem cells with abilities to self-renew and differentiate into multiple blood cell lineages. Adult HSCs reside in the bone marrow microenvironment and are tightly regulated by complex cell-intrinsic and extrinsic factors. Lipids, one of the essential nutrients for the organism, are used in energy storage and metabolism and have important roles in many pivotal biological processes. However, the role of lipid metabolism in hematopoiesis has not been fully explored. Here, this review summarizes and discusses recent progress on lipid metabolism in the regulation of HSCs fate and function, focusing on the underlying mechanisms related with fatty acid synthesis, fatty acid oxidation and cholesterol transportation.
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