The Regulatory Role of Bone Marrow Adipocytes in Hematopoiesis
XIE Yueqiao, MA Xiaotong*
The bone marrow cavity is the place where hematopoiesis occurs. BMAds (bone marrow adipocytes) reside in the bone marrow and constitute the largest cell population in the bone marrow cavity closely contacting with hematopoietic cells. BMAds and osteoblasts originate from bone MSCs (marrow mesenchymal stem cells). The importance of bone marrow fat in bone health has long been recognized, but its complex role in regulating hematopoiesis has not attracted attention until recently. The effects of bone marrow fat on hematopoiesis reported by different research teams are often contradictory. Deciphering the regulatory mechanisms of bone marrow fat under different conditions in the hematopoietic system may be helpful to fully understand the complex bidirectional interactions between the bone marrow microenvironment and HSCs (hematopoietic stem cells). It may provide novel targets for hematological diseases in the future. This article will review the latest advances in the role of BMAds in hematopoiesis regulation.
CN
EN