Research Progress on Mechanism of Hematopoietic Memory in Hematopoietic Stem/Progenitor Cells
GUO Rongxia, GAO Rongmei, HUANG Qingxiang, MA Fengxia*
Adaptive immunity and innate immunity are two relatively independent and closely interrelated immune responses. With the introduction of the concept of TI (trained immunity) in 2011, which indicates that innate immune cell also has immune memory, the traditional view that only adaptive immunity can establish immune memory has been strongly challenged. However, mature innate immune cells usually have short lifespan, and blood homeostasis is maintained by HSPCs (hematopoietic stem/progenitor cells) in bone marrow. Therefore, it has been a hotspot in the field of immunology and hematopoiesis that how HSPCs maintain long-term or short-term memory of innate immune cells. Recent studies have shown that HSPCs also have immune memory like TI, which is termed as “hematopoietic memory”. And the mechanism of this phenomenon mainly involves epigenetic modification, metabolic reprogramming, expressional regulation of cytokines and their receptors. This review will summarize the progress of hematopoietic memory in recent years.
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