Research Progress on the Role and Mechanism of S100A10 in the Pathogenesis of Depression
HUA Ruifang, ZHANG Jingjing, DING Yan, YANG Pei, LIU Rongxun, LIU Kerui, WANG Hui*
Depression is a chronic and recurrent psychiatric disorder associating with the alterations of brain circuitries, neuronal networks, molecular signaling pathways and neurotransmitters. S100A10, a member of S100 family, is wildly expressed in the central nervous system, including prefrontal cortex, hippocampus, amygdala and other brain areas in emotion modulation. It interacts with serotonergic receptor, metabotropic glutamate receptor, brain-derived neurotrophic factor and so on. It has attracted much attention in the pathogenesis of depression. Based on the previous research and the recent insights, the focus of this review is to provide an update on the roles of S100A10 and its neural and molecular mechanism in the pathogenesis of depression, which provides new avenues for further research and clinical treatment.
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