Influences of Heat Stress-Induced Oxidative Stress on Male Reproduction
DENG Chengchen, HUO Yuannan, WANG Xianzhong*
Mammalian spermatogenesis is a temperature-dependent process. Spermatogenesis and semen quality will be severely compromised under high-temperature. Heat stress escalates the synthesis of reactive oxygen species and induces oxidative stress. Oxidative stress results in apoptosis, autophagy, and DNA damage of testicular cells, impairment of the blood-testis-barrier, as well as abnormal secretion of androgen, and causes male infertility. This paper outlines the intrinsic and extrinsic factors that increase testicular heat stress and discusses the molecular mechanisms involved in response of testicular cells under oxidative stress. Moreover, this review gives an outlook on how to reduce effects of heat stress on male reproduction.
CN
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