Advances in Molecular Regulation for the Development of Zebrafish Primordial Germ Cells
ZHANG Xiaoyuan, LI Yiping, LI Shifeng*
PGCs (primordial germ cells) are the earliest germ cells appeared in organism. PGCs go through proliferation and migration, and reach the sexual gland. Then, by a series of differentiation, PGCs finally become sperms or eggs. For zebrafish, PGCs appear at 3 hpf (hours post fertilization), while mouse PGCs appear at 7.25 dpf (days post fertilization). During the development of zebrafish PGCs, onset of cell migration, change of cell number and maintenance of cell pluripotency are under serious gene regulation, thus ensuring normal development of PGCs. This review summarizes relatedly regulating molecules in the development of zebrafish PGCs in recent years, and recognizing the function of these regulating molecules will be a good help for the research of the development of mammalian germ cells and human reproductive health.
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