Experimental Teaching Reform of Cell Biology: Observation of Chromosome in Prophase I of Meiosis
LI Jiaxiang1#, LIU Libo1#, WEI Min2, LI Xiaoxue2, ZENG Xianlu2, BA Xueqing2, WANG Ruoxi1*
Meiosis is a specialized cell division process that generates haploid gametes from diploid germ cells. Compared with mitosis, meiosis requires an extra set of systems to ensure precise halving of chromosome. Moreover, the partial exchange of homologous chromosomes is the structural basis for the introduction of gene recombination during meiosis and the achievement of individual genetic diversity of offspring. All of these meiosisspecific events are closely related to the process of meiosis prophase I. However, in the current undergraduate experimental teaching of Cell Biology, it is hard to set up meiosis experiments, because of more restricted access to materials and the difficulty of observing the morphological structure of chromosomes in all periods of meiosis I at the same time. Based on the experience accumulated in scientific research, the authors tried to use Caenorhabditis elegans as material to observe the morphological structure of chromosomes in each stage of meiosis prophase I. It aims to enrich the teaching content of Cell Biology Experiments for undergraduates through teaching reform and practice. Students will gain a deeper understanding of the dynamic process of meiosis and the difference between mitosis and meiosis, and then gain a deeper understanding of the significance of meiosis for the evolution of life.
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