The Role of m⁶A Modification in Adipogenesis

Obesity is a kind of metabolic disorder caused by excessive fat accumulation, and the prevalence of obesity has been increasing globally. Obesity is strongly associated with metabolic diseases and cancer. Therefore, it’s important to understand the processes and molecular mechanisms of adipogenesis. m6A modification is the most prevalent and abundant internal modification in eukaryotes, which can regulate multiple aspects of RNA metabolism, such as mRNA stability, transcription, processing, splicing, transport and degradation. As a dynamic and reversible post-transcriptional modification, m6A modification participates in various biological processes, including embryonic development, spermatogenesis, DNA damage, tissue homeostasis, and adipogenesis. This review summarizes recent studies about the effect of m6A modification on adipogenesis, which may help the researcher better understand the mechanisms of adipogenesis at post-transcriptional level, and provide possible ways for future studies.

CSTR: 32200.14.cjcb.2021.10.0020