The Research Progress and Application of Gut Microbiome in GVHD after the Allogeneic Hematopoietic Stem Cell Transplantation
CHEN Dan, WANG Xiao, YAO Hao*
HSCT (hematopoietic stem cell transplantation) is an effective treatment for high risk hematological malignancies and other hematologic disease. However, GVHD (graft-versus-host disease) blocks its wide application. GM (gut microbiomes) can promote metabolism, resist pathogens and regulate the immnue system by maintaining diversity and related metabolites, which have an impact on human health. In particular, allo-HSCT (allogeneic hematopoietic stem cell transplantation) patients are treated with drugs and exogenous cells, which can destroy
the dynamic balance between the immune system and intestinal microbiomes. Therefore, GM can not only be used as an independent predictor of mortality after transplantation, but also be a target of prevention and treatment effect of GVHD after allo-HSCT through nutritional support, probiotics, clinical usage of antibiotics and FMT (fecal microbiota transplantation). This article reviewed the research progress and application of intestinal microbiomes in GVHD after allo-HSCT, which can provide new ideas for the prevention and treatment of GVHD after allo-HSCT.
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