Research Progress on the Role of NRF2 Signaling Pathway in Breast Cancer
DING Muyao, ZHANG Qian, YUAN Shengtao, SUN Li*
Breast cancer has become one of the most common tumors in women, seriously endangering women’s physical and mental health and even life-threatening. NRF2 (nuclear factor erythroid-derived factor 2-related factor), mainly activates downstream transcription by binding to the ARE (antioxidant response element) on the promoter of the target gene. Many recent studies have shown that NRF2 plays an important role in the development of breast cancer. This article mainly summarizes the signaling pathways in breast cancer that can affect the development of breast cancer by interacting with NRF2, including classic signaling pathways such as protein kinase B (AKT), P53, and STAT3 (signal transducer and activator of transcription 3). It also clarified the influence of the interaction between NRF2 and microRNA on the development of breast cancer. Due to the importance of NRF2 in breast cancer, this article also summarizes the classic NRF2 activators and inhibitors. These compounds may play an important role in the prevention and adjuvant treatment of breast cancer in the future.
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