The Effect of Regulation of Toxicant Metabolism on High Incidence of Lung Cancer in Xuanwei Area
WU Shuangshuang, WANG Yajie, FU Yu, CHU Jiang*, KONG Xiangyang*
Xuanwei city, Yunnan province, China, has a high incidence of lung diseases (especially lung cancer and chronic obstructive pulmonary disease), and has the highest mortality rate of female lung cancer in the country. Therefore, it is particularly important for local residents to understand the causes of the high incidence of lung cancer in this area. The occurrence of lung cancer is often the result of the joint action of environmental and genetic factors. In this area, bituminous coal has been used as living fuel for a long time. Both the burning and smoking of bituminous coal will release a large amount of PAHs (polycyclic aromatic hydrocarbons). The metabolic process of PAHs in the body involves in the role of various toxic metabolic enzymes, and the gene polymorphism of toxic metabolic enzymes will affect the susceptibility of individuals to lung cancer. The purpose of this paper is to explore the polycyclic aromatic hydrocarbons metabolism in the body, the polymorphism of toxic metabolic enzymes gene and the influence of genetic susceptibility on the high incidence of lung cancer in Xuanwei area.
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