Advances in the Molecular Mechanism of Conjugated Linoleic Acids in Decreasing Fat Deposition
ZOU Zhaoxia, LI Ying*
The fat content and composition of fatty acids in animal derived food have become the main factors to measure the quality of animal food. The size of adipose tissue is determined by the number and volume of adipocytes. The apoptosis of fat cell also directly leads to the decrease of adipocyte number. CLAs (conjugated linoleic acids) are a class of octadecadienoic acid isomers with conjugated double bonds, and the active form of c9, t11-CLA and t10, c12-CLA can reduce the content of body adipose tissue through regulating the expression of a variety of nuclear transcription factors which relate to the adipogenic, fatty acid uptake, oxidation and fat synthesis, thus changing the fatty acid composition, improving meat quality. The recent progress about the role of CLAs on adipocyte proliferation, differentiation, apoptosis, lipid metabolism, body fat reduction, the expression of the transcription factors and signaling pathway were summarized, and the application of CLAs in adipogenesis and reducing body fat in animals were discussed in this review. It may provide a useful reference for CLAs in animal production and application as functional food in people’s lives.
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