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Lentivirus-mediated RNA Interference
Xin Yang, Ying-He Hu*
Key Laboratory of Brain Functional Genomics, Ministry of Education & Science and Technology Commission of Shanghai Municipality, East China Normal University, Shanghai 200062, China
Abstract: RNA interference is a process in which double-stranded RNA triggers the degradation of a homologous mRNA. Lentivirus vector can introduce interested sequence into dividing and nondividing cells efficiently. Lentivirus-mediated RNA interference can be used to inhibit the expression of homologous genes in different mammalian cells， both in vitro and in vivo. Extensive studies indicated that it was an important tool for gene functional analysis and gene therapy.
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